Antibiotics are commonly used in the outpatient setting, particularly in the treatment of upper respiratory tract infection. These infections include acute bronchitis, sore throat, ear infection, and sinusitis. However, the benefits of antibiotics are highly dependent upon the specific infection. Antibiotics are associated with complications in some patients, including allergies and other side effects. Additionally, zinc and other agents offer potential benefit in the treatment of infection, particularly those associated with viruses. B. Joseph Guglielmo, Professor and Dean at the UCSF School of Pharmacy, provides guidance in the safe, effective use of antibiotics in the treatment of upper respiratory tract infection.