The panelists discuss their global clinical investigation programs, highlighting creative research approaches and lessons learned. Topics include innovative methods for studying treatment of tuberculosis, infectious and inflammatory eye diseases, and mental health disorders in resource-constrained environments around the world. Each speaker provides case examples, discusses achievements, and shares his or her perspectives on opportunities for furthering UCSF global clinical research initiatives. Panelists: Nisha Acharya, Associate Professor, Departments of Ophthalmology and Epidemiology; Susan Meffert, Assistant Professor, Department of Psychiatry; Payam Nahid, Associate Professor, Department of Medicine. Saam Morshed, Assistant Professor, Department of Orthopaedic Surgery moderates.